oxidative stress plays a major role in the pathogenesis of alzheimer's disease (ad) of sporadic origin. the expression of dhcr24 (seladin-1), marker for neuronal oxidative stress and degeneration, has been reported to be altered in the brains of ad patients. in the present study, we investigated the effect of trimetazidine (tmz) on the hippocampal oxidative parameters and the expression of dhcr...

The effect of gallic acid on oxidative stress parameters and hippocampal cell density in ischemia-renal reperfusion model

Background: The most important cause of neurodegeneration in Alzheimer's disease (AD) is associated with inflammation and oxidative stress. Probiotics are microorganisms that are believed to be beneficial to human and animals. Probiotics reduce oxidative stress and inflammation in some cases. Therefore, this study determined the effects of probiotics mixture on the biomarkers of oxidative stres...

Hippocampal neurogenesis in the subgranular zone (SGZ) of dentate gyrus (DG) occurs throughout life and is regulated by pathological and physiological processes. The role of oxidative stress in hippocampal neurogenesis and its response to exercise or neurodegenerative diseases remains controversial. The present study was designed to investigate the impact of oxidative stress, treadmill exercise...

Chronic unpredictable mild stress (CUMS) induces hippocampal oxidative stress. H2S functions as a neuroprotectant against oxidative stress in brain. We have previously shown the upregulatory effect of H2S on BDNF protein expression in the hippocampus of rats. Therefore, we hypothesized that H2S prevents CUMS-generated oxidative stress by upregulation of BDNF-TrkB pathway. We showed that NaHS (0...

Chronic alcohol consumption causes hippocampal neuronal impairment, which is associated with oxidative stress and apoptosis. Carvacrol is a major monoterpenic phenol found in essential oils from the family Labiatae and has antioxidative stress and antiapoptosis actions. However, the protective effects of carvacrol in ethanol-induced hippocampal neuronal impairment have not been fully understood...

Background and Aim: The purpose of the present study is to provide a basis for use Curcuma longa extract as therapeutic agent status epilepticus. Methods: effect on epilepticus in rat model was investigated. rat’s SE induced by pilocarpine evaluated through measurement seizure duration, brain oedema hippocampal oxidative stress this model. Results: In pre-treated with (400mg/kg) water content l...

BACKGROUND Chronic stress contributes to the development of brain disorders, such as neurodegenerative and psychiatric diseases. Oxidative damage is well known as a causative factor for pathogenic process in brain tissues. The aim of this study is to evaluate the neuroprotective effect of a 30% ethanol extract of Aquilariae Lignum (ALE) in repeated stress-induced hippocampal oxidative injury. ...

background: an important role for oxidative stress, as a consequence of epileptic seizures, has been suggested. coriandrum sativum has been shown that have antioxidant effects. central nervous system depressant effects of c. sativum have also been reported. in this study, the effects of hydroalcoholic extract of aerial parts of the plants on brain tissues oxidative damages following seizures in...